USP2 antibody

Catalog No. ABIN7120503

This anti-USP2 antibody is a Rabbit Polyclonal antibody detecting USP2 in WB, ELISA, IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for USP2 antibody (ABIN7120503)

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-USP2 Antibody

Purpose: USP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 2

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200,IF:1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Alternative Name: USP2

Background:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 2|41 kDa ubiquitin-specific protease|Deubiquitinating enzyme 2|Ubiquitin thioesterase 2|Ubiquitin-specific-processing protease 2|USP2|UBP41

Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1(By similarity).

Molecular Weight: 68 kDa

Gene ID: 10869

UniProt: O75604